Inhibitors to tubulin polymerization

A compound of the general formula (1)

• 218
• or a pharmaceutically acceptable salt thereof, wherein
• R1 and R2 are independently selected from the group consisting of —H, halo, C1-C6 alkyl, halogenated-C1-C6-alkyl, and —OR4,
• R4 is selected from the group consisting of C1-C6 alkyl, optionally substituted aryl, and optionally substituted aryl-C1-C6-alkyl,
• or wherein R1 and R2 together with the carbon to which they are attached form a heterocyclyl;
• L is selected from the group consisting of a covalent bond, C1-C6 alkyl, —C(O)—, and —(CH2)0-3C(H)(R5)—,
• R5 is selected from the group consisting of C1-C6 alkyl, aryl, aryl-C1-C6-alkyl, —R6—S—R7, —R6—C(O)OR7, and —R6—O—R7, wherein R6 and R7 are C1-C6 alkyl;
• and
• R3 is selected from the group consisting of H, C1-C6 alkyl, hydroxy C1-C6 alkyl, optionally substituted C3-C8-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl alkyl, —OR8, —C(O)OR9, —N(R10)R11,
• R8 is C1-C6 alkyl or hydroxy C1-C6 alkyl, and
• R9, R10, and R11 are C1-C6 alkyl.