2-pyridinamine compositions and related methods

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula

• 43
• or a pharmaceutically acceptable salt thereof, wherein
• (a) R1 is H or a substituent bound at either the 5 or 6 ring position and selected from the group consisting of alkyl, alkenyl, alkynyl, thienyl, furanyl, pyrrolyl, phenyl, pyrimidinyl, substituted pyrimidinyl, pyridinyl, substituted pyridinyl, phenyl alkenyl, substituted phenyl alkenyl, benzo[b]thien-2-yl, 2-benzofuranyl and substituted phenyl,
• said substituted phenyl having the formula
• 44
• wherein (i) R6 is selected from the group consisting of H, OH, halogen, alkylamino, dialkylamino, hydroxy-substituted dialkyl amino, lower alkyl, acidic lower alkyl, alkoxy, halogen-substituted lower alkoxy, phenyl and morpholinyl, and (ii) R7 represents between one and four substituents which may be the same or different and are selected from the group consisting of H, halogen, amino, alkyl, lower alkyl, halogen-substituted lower alkyl, alkylamino, dialkylamino, acidic lower alkoxy, alkoxy, halogen-substituted lower alkoxy, alkoxy and phenylalkoxy, with the proviso that R6 and R7 may be fused to form 2-naphthyl or 1,3, benzodioxolyl;
• (b) Each R2 is independently H or lower alkyl;
• (c) Each R3 is independently selected from the group consisting of H, lower alkyl, amino, alkylamino, dialkylamino and lower alkoxy;
• (d) R4 is H, alkoxy or morpholinyl, with the proviso that R4 may be fused with R3 to form 2,3-dihydro-1,4-benzodioxinyl or 9-alkyl 9H carbazolyl;
• and
• (e) R5 is H or lower alky.