Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof
AssigneeAMAG Pharmaceuticals, Inc.
InventorsErnest V. Groman, Kenneth G. Paul, Timothy B. Frigo, Howard Bengele, Jerome M. Lewis
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Abstract
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.
Claims23
An improved method of administering to a mammalian subject a polysaccharide iron oxide complex, wherein the improvement comprises administering a carboxyalkylated reduced polysaccharide iron oxide complex having an extent of carboxyalkylation sufficient to produce decreased edematous response to the carboxyalkylated complex in comparison to an edematous response to an administered polysaccharide that has not been thus carboxyalkylated.
An improved method of administering to a mammalian subject a polysaccharide wherein the polysaccharide is dextran and wherein the improvement comprises administering a carboxyalkylated reduced dextran having an extent of carboxyalkylation sufficient to produce decreased edematous response to the carboxyalkylated dextran in comparison to an edematous response to an administered dextran that has not been thus carboxyalkylated.
An improved method of magnetic resonance imaging (MRI) wherein the improvement comprises administering to a subject an effective dose of a carboxyalkylated reduced polysaccharide iron oxide MRI contrast agent to facilitate magnetic resonance imaging (MRI) of a tissue or organ wherein upon administering the carboxyalkylated reduced polysaccharide MRI contrast agent there is a decreased edematous response in comparison to an administered polysaccharide MRI contrast agent that has not been thus carboxyalkylated.
An improved method of magnetic resonance imaging (MRI), wherein the improvement comprises administering to a subject successive effective doses of a carboxyalkylated reduced polysaccharide iron oxide MRI contrast agent to facilitate successive magnetic resonance imaging of a tissue or organ wherein upon administering the carboxyalkylated reduced polysaccharide MRI contrast agent there is a decreased edematous response in comparison to an administered polysaccharide MRI contrast agent that has not been thus carboxyalkylated.
An improved method for obtaining a composition for pharmacological administration from a polysaccharide, wherein the improvement comprises prior to administering:
- reducing the polysaccharide;
- and
- carboxyalkylating to an extent sufficient to produce a decreased edematous response in the subject to the administered polysaccharide composition in comparison to an edematous response in the subject to an administered polysaccharide that has not been thus reduced and carboxyalkylated.
An improved method for obtaining a composition for pharmacological administration from a dextran, wherein the improvement comprises:
- reducing the dextran;
- and,
- carboxyalkylating the dextran to provide an extent of carboxyalkylation sufficient to produce a decreased edematous response to the administered dextran composition in a subject in comparison to an edematous response in a subject to an administered polysaccharide that has not been thus reduced and carboxyalkylated.
Dependencies are inferred from the claim text.