Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid
OwnerSteven C. Quayinventor
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Abstract
Methods and compositions are disclosed that provide acetylcholinesterase inhibitors for the prevention and treatment of diseases and disorders of the central nervous system, including dementia such as Alzheimer's disease, to the central nervous system via intranasal delivery. The methods and compositions of the present invention provide therapeutic concentrations of the acetylcholinesterase inhibitor in the cerebrospinal fluid of a mammal without the attendant disadvantages, risks and side effects of oral or injection delivery.
Claims62
A pharmaceutical composition for treatment or prevention of a disease or condition in a mammal in need of treatment by therapeutic administration of an acetylcholinesterase inhibitor, comprising:
- a. a liquid or gel solution for nasal administration of at least one acetylcholinesterase inhibitor;
- and
- b. at least one permeation-enhancement agent for transmucosal drug uptake.
Dependencies are inferred from the claim text.