Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
OwnerIan R. Livingstoneinventor
Life of this patent
Estimating the term…
Abstract
The present invention describes a method for the treatment and/or prevention of migraine and associated symptoms (nausea, vomiting, photophobia, phonophobia, etc.) comprising co-therapy with a therapeutically effective amount of one or more anti-migraine agents and one or more anticonvulsant derivatives.
Claims31
A method for treating migraine in a subject in need thereof comprising co-therapy with a therapeutically effective amount of an anti-migraine agent and a compound of the formula (I):
- 7
- wherein
- X is CH2 or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (I)I:
- 8
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
The method of claim 13 wherein the triptan is selected from the group consisting of sumatriptan, naratriptan, rizatriptan, zolmitriptan, eletriptan, frovatriptan and almotriptan.
A method for treating the nausea, photophobia or phonophobia associated with a migraine headache in a subject in need thereof comprising co-therapy with a therapeutically effective amount of an anti-migraine agent and a compound of the formula (I):
- 9
- wherein
- X is CH2 or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (I)I:
- 10
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
A method for preventing migraine in a subject in need thereof comprising co-therapy with a therapeutically effective amount of an anti-migraine agent and a compound of the formula (I):
- 11
- wherein
- X is CH2 or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (I)I:
- 12
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
Dependencies are inferred from the claim text.