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US 2003/0224989 A1Published application
Compositions and methods for treatment of osteoarthritis
OwnerKerry Quinn, Gregory L. Pahelinventors
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OwnerKerry Quinn, Gregory L. Pahelinventors
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The present invention is based upon methods of treating musculoskeletal or pro-inflammatory conditions and pathologies in mammals using. Methods of using the polynucleotide sequences and the the polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using OAX polynucleotide sequences and the OAX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. OAX collectively refers to any of six variant OAX sequences, variously designated OA1, OA2, OA3, and OA4.
A method of promoting the proliferation of chondrocyte cells comprising contacting the at least one chondrocyte cell with a composition comprising at least one polypeptide, wherein the polypeptide is an OAX polypeptide.
A method of treating an inflammatory pathology in a subject comprising administering to the subject a composition comprising a polypeptide wherein the polypeptide is an OAX polypeptide.
A method of promoting cartilage matrix repair in a subject comprising administering a OAX polypeptide.
A method of ameliorating a pro-inflammatory pathology in a subject comprising administering to the subject a composition said compositions comprising a combination of an OAX polypeptide, a growth factor, and a candidate therapeutic.
A method of preparing a pharmaceutical composition comprising combining at least one polypeptide effective in treating an inflammatory pathology with a pharmaceutically acceptable carrier, wherein the polypeptide is a OAX polypeptide.
The method described in claim 39 wherein the inflammatory pathology is osteoarthritis.
Dependencies are inferred from the claim text.