Transport peptides such as C-terminal Erns peptide and analogues thereof

A pharmaceutical composition comprising:

• a peptide module or equivalent of said peptide module having heparin binding activity, said peptide module comprising an amino acid sequence selected from the group of amino acid sequences located at:
• from about amino acid position 194 to about amino acid position 220 in a pestiviral Erns protein RNase,
• from about amino acid position 59 to about amino acid position 88 in a L3 loop of a cytotoxic RNase of a ribosome-inactivating protein, or
• from about amino acid position 187 to about amino acid position 223 in a respiratory syncytial virus G-protein, and
• mixtures of any thereof;
• and
• a compound for delivery.

A method of eliciting antibiotic activity in a subject, said method comprising:

• administering, to the subject, a peptide module or equivalent of said peptide module having heparin binding activity, said peptide module comprising an amino acid sequence selected from the group of amino acid sequences located at:
• from about amino acid position 194 to about amino acid position 220 in a pestiviral Erns protein RNase,
• from about amino acid position 59 to about amino acid position 88 in a L3 loop of a cytotoxic RNase of a ribosome-inactivating protein, or
• from about amino acid position 187 to about amino acid position 223 in a respiratory syncytial virus G-protein, and
• mixtures thereof.

A method for translocating a compound through a cell's membrane, said method comprising:

• providing said compound with an isolated peptide module or equivalent of said isolated peptide module having heparin binding activity, said peptide module comprising an amino acid sequence selected from the group of amino acid sequences located at:
• from about amino acid position 194 to about amino acid position 220 in a pestiviral Erns protein RNase,
• from about amino acid position 59 to about amino acid position 88 in a L3 loop of a cytotoxic RNase of a ribosome-inactivating protein, or
• from about amino acid position 187 to about amino acid position 223 in a respiratory syncytial virus G-protein, and
• mixtures thereof;
• and
• contacting said compound and isolated peptide module or functional equivalent thereof with the cell.