Photosensitizer conjugates for targeting intracellular pathogens
AssigneeThe General Hospital Corporation
InventorsTayyaba Hasan, Jerome Gross, Gerard J. Nau
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Abstract
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
Claims53
A method for treating a subject having a disorder associated with an intracellular pathogen, the method comprising administering to the subject a molecular conjugate comprising
- (a) a photosensitizer and
- (b) a targeting moiety, wherein the targeting moiety targets the conjugate to the intracellular pathogen or to an infected host cell.
A molecular conjugate comprising
- (a) a photosensitizer and
- (b) a targeting moiety, wherein the targeting moiety targets the conjugate to an intracellular pathogen or to an infected host cell.
A method for treating a subject having tuberculosis, the method comprising administering to the subject a molecular conjugate comprising
- (a) a photosensitizer and
- (b) a targeting moiety, wherein the targeting moiety targets the conjugate to a Mycobacterium tuberculosis cell.
A method of killing a bacterial cell, the method comprising contacting the cell with pl-ce6 or BPD.
A method for treating a subject having a disorder associated with an intracellular pathogen, the method comprising administering to the subject:
- (1) an antibiotic and (2) a molecular conjugate comprising
- (a) a photosensitizer and
- (b) a targeting moiety, wherein the targeting moiety targets the conjugate to the intracellular pathogen or to an infected host cell.
A method for killing a Mycobacterial cell, the method comprising:
- (a) contacting the cell with a molecular conjugate comprising a photosensitizer;
- and
- (b) irradiating the cell, wherein the irradiation has a wavelength that causes the photosensitizer to produce a cytotoxic effect.
A method of treating a subject having an infectious disease of the lung, the method comprising:
- (a) administering to the subject a molecular conjugate comprising a photosensitizer;
- and
- (b) irradiating the lung, wherein the irradiation has a wavelength that causes the photosensitizer to produce a cytotoxic effect.
Dependencies are inferred from the claim text.