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US 2003/0223977 A1Published application
Kunitz domain mutants as cathepsin G inhibitors
OwnerArthur Charles Ley, Sonia Kosow Guterman +4inventors
InventorsArthur Charles Ley, Sonia Kosow Guterman, William Markland, Rachel Baribault Kent, Bruce Lindsay Roberts, Robert Charles Ladner
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Abstract
Novel small proteins which bind cathepsin G have been identified. These are useful as inhibitors of excessive cathepsin G activity in patients.
Claims49
A non-naturally occurring or purified protein which inhibits human cathepsin G, and which is a protein comprising a mutant Kunitz domain,
- where
- the residue (a) corresponding to BPTI position 15 is Met or Phe,
- the residue (b) corresponding to BPTI position 16 is Ala, Gly or Asp,
- the residue (c) corresponding to BPTI position 17 is Phe, Ile or Glu,
- with the proviso that residues 15-17 are not Phe-Ala-Phe.
2 more elements
A method of treating a disease or condition characterized by excessive cathepsin G activity in a human subject suffers from inflammation.
Dependencies are inferred from the claim text.