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US 2003/0217370 A1Published application
Transgenic animal expressing alpha-synuclein and uses thereof
OwnerBenoit I. Giasson, John Q. Trojanowski +1inventors
InventorsBenoit I. Giasson, John Q. Trojanowski, Virginia M.-Y. Lee
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Abstract
The present invention relates to transgenic animals expressing A53T α-Syn protein which are models for neurodegenerative disease progression. These animals may be used for screening candidate drug compounds effective against neurodegenerative diseases and other diseases involving α-synucleinopathy.
Claims4
A transgenic animal comprising a nucleotide sequence encoding a heterologous α-synuclein protein operably linked to at least a portion of a regulatory region of a prion gene, wherein said transgenic animal expresses human α-synuclein protein.
Dependencies are inferred from the claim text.