Cascade esters of camptothecins and methods of treating cancer using these compounds

A compound of formula I:

• 12
• wherein R is H, NO2, NH2, N3, a halogen, carboxyl, a C1-16 alkyl group, a C1-16 alkyenyl group, a C3-8 cycloalkyl group, a C1-8 alkoxyl group, an aroxyl group, CN, SO3H, a C1-8 halogenated alkyl group, (CH2)nNR 27, hydroxyl, SH, SR8, a carbonyl group, a SiR310;
• C1-12 alkenyl group, CF3, CCl3, CH2F, CH2Cl, CHF2, CHCl2, OH, or OR12 wherein the R group is respectively positioned at the 9, 10, 11, or 12 position of ring A;
• R12 is a C1-8 alkyl group, a C1-8 alkenyl group, or an aromatic group;
• R7 is H or a C1-8 alkyl group;
• n is an integer of 1 to 8;
• R8 is a C1-8 alkyl group or a phenyl group;
• R10 is a C1-4 alkyl group;
• X is H, a C1-8 alkyl group, a C1-8 alkenyl group, a C1-8 alkoxyl group, an aroxyl group, a SiR311 group, or CH2 NZY;
• X1 is an alkylene group or an aromatic radical, and R1 is an alkyl group, a halo alkyl group, or an aromatic group, or ester of acetylsalicyclic acid, Acemetacin-yl or derivatives thereof.