An amide derivative of the Formula (I):
- 13
- wherein:
- G is N or CH;
- R1 is hydroxy, halo, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy, carbamoyl, formyl, sulphamoyl, C1-6alkyl, C2-6alkenyl, C2-4alkynyl, C1-6alkoxy, —O—(C1-3alkyl)-O—, C1-6alkyls(O)n— (wherein n is 0-2), N—C1-4alkylamino, N,N-(C1-6alkyl)2amino, C1-6alkoxycarbonyl, N—C1-6alkylcarbamoyl, N,N-(C1-6alkyl)2carbamoyl, C2-6alkanoyl, C1-6alkanoyloxy, C1-6alkanoylamino, N—C1-6alkylsulphamoyl, N,N—(C1-6alkyl)2sulphamoyl, C1-6alkylsulphonylamino, C1-6alkylsulphonyl-N-(C1-6alkyl)amino,
- or R1 is of the formula (Ia):
- A-(CH2)p—B— (IA)
- wherein A is halo, hydroxy, C1-6alkoxy, C1-6alkylS(O)n— (wherein n is 0-2), cyano, amino, N—C1-6alkylamino, N,N-(C1-6alkyl)2amino, carboxy, C1-6alkoxycarbonyl, carbamoyl, N—C1-6alkylcarbamoyl or N,N—(C1-6alkyl)2carbamoyl, p is 1-6, and B is a bond, oxy, imino, N-(C1-6alkyl)imino or —C(O)NH—, with the proviso that p is 2 or more unless B is a bond or —C(O)NH—,
- or R1 is of the Formula (IB):
- D-E- (IB)
- wherein D is aryl, heteroaryl or heterocyclyl and E is a bond, C1-6alkylene, C1-6alkyleneoxy, oxy, imino, N-(C1-6alkyl)imino, C1-6alkyleneimino, N-(C1-6alkyl)-C1-6alkyleneimino, C1-6alkyleneoxy-C1-6alkylene, C1-6alkyleneimino-C1-6alkylene, N-(C1-6alkyl)-C1-6alkyleneimino-C1-6alkylene, —C(O)NH—, —SO,NH—, —NHSO2— or C1-6alkanoylimino, and any aryl, heteroaryl or heterocyclyl group in a R1 group may be optionally substituted with one or more groups selected from hydroxy, halo, C1-6alkyl, C1-6alkoxy, carboxy, C1-6alkoxycarbonyl, carbamoyl, N—C1-6alkylcarbamoyl, N,N—(C1-6alkyl)2carbamoyl, C2-6alkanoyl, amino, N—C1-6alkylamino and N,N—(C1-6alkyl)2amino,
- and any heterocyclyl group in a R1 group may be optionally substituted with one or two oxo or thioxo substituents,
- and any of the R1 groups defined hereinbefore which comprises a CH2 group which is attached to 2 carbon atoms or a CH3 group which is attached to a carbon atom may optionally bear on each said CH2 or CH3 group a substituent selected from hydroxy, amino, C1-6alkoxy, N—C1-6alkylamino, N,N-(C1-6alkyl)2amino and heterocyclyl-;
- R2 is hydrogen, halo, C1-6alkyl, C2-6alkenyl or C2-6alkynyl;
- R3 is hydrogen, halo, C1-6alkyl, C2-6alkenyl or C2-6alkynyl;
- R4 is hydrogen, hydroxy, C1alkyl, C1alkoxy, amino, N—C1-6alkylamino, N,N-(C1-6alkyl)2amino, hydroxyC2-6alkoxy, C1-6alkoxyC2-6alkoxy, aminoC2-6alkoxy, N—C1-6alkylaminoC2,alkoxy, N,N-(C1-6alkyl)2aminoC2-6alkoxy or C3-7cycloalkyl,
- or R4 is of the Formula (IC):
- -K-J (IC)
- wherein J is aryl, heteroaryl or heterocyclyl and K is a bond, oxy, imino, N—(C1-6alkyl)imino, oxyC1-6alkylene, iminoC1-6alkylene, N-(C1-6alkyl)iminoC1-6alkylene, —NHC(O)—,
- —SO2NH—, —NHSO2— or —NHC(O)—C1-6alkylene-,
- and any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted by one or more groups selected from hydroxy, halo, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy, carbamoyl, formyl, sulphamoyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, —O—(C1-3alkyl)-O—, C1-6alkylS(O)n— (wherein n is 0-2), N—C1-6alkylamino, N,N-(C1-6alkyl)2amino, C1-6alkoxycarbonyl, N—C1-6alkylcarbamoyl, N,N-(C1-6alkyl)2carbamoyl, C2-6alkanoyl, C1-6alkanoyloxy, C1-6alkanoylamino, N—C1-6alkylsulphamoyl, N,N-(C1-6alkyl)2sulphamoyl, C1-6alkylsulphonylamino and C1-6alkylsulphonyl-N-(C1-6alkyl)amino,
- or any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted with one or more groups of the Formula (IA′):
- —B1—(CH2)p-A1 (IA′)
- wherein A1 is halo, hydroxy, C1-6alkoxy, cyano, amino, N—C1-6alkylamino, N,N-(C1-6alkyl)2amino, carboxy, C1-6alkoxycarbonyl, carbamoyl, N-C1-6alkylcarbamoyl or N,N-(C1-6alkyl)2carbamoyl, p is 1-6, and B1 is a bond, oxy, imino, N-(C1-4alkyl)imino or —NHC(O)—, with the proviso that p is 2 or more unless B1 is a bond or —NHC(O)—;
- or any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted with one or more groups of the Formula (IB′):
- -E1-D1 (IB′)
- wherein D1 is aryl, heteroaryl or heterocyclyl and E1 is, a bond, C1-6alkylene, oxyC1-6alkylene, oxy, imino, N-(C1-6alkyl)imino, iminoC1-6alkylene, N—(C1-6alkyl)iminoC1-6alkylene, C1-6alkylene-oxyC1-6alkylene, C1-6alkylene-iminoC1-6alkylene, C, alkylene-N—(C6alkyl)-iminoC1-6alkylene, —NHC(O)—, —NHSO2—, —SO2NH— or —NHC(O)—C1-6alkylene-, and any aryl, heteroaryl or heterocyclyl group in a substituent on R4 may be optionally substituted with one or more groups selected from hydroxy, halo, C1-6alkyl, C1-6alkoxy, carboxy, C1-6alkoxycarbonyl, carbamoyl, N—C3alkylcarbamoyl, N,N-(C1-6alkyl)2carbamoyl, C2-6alkanoyl, amino, N—C1-6alkylamino and N,N-(C1-6alkyl)2amino,
- and any C3-7cycloalkyl or heterocyclyl group in a R4 group may be optionally substituted with one or two oxo or thioxo substituents,
- and any of the R4 groups defined hereinbefore which comprises a CH2 group which is attached to 2 carbon atoms or a CH3 group which is attached to a carbon atom may optionally bear on each said CH2 or CH3 group a substituent selected from hydroxy, amino, C1-6alkoxy, N—C1-6alkylamino, N,N-(C1-6alkyl)2amino and heterocyclyl;
- R5 is hydrogen, halo, trifluoromethyl, cyano, nitro, amino, hydroxy, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, N—C1-6alkylamino or N,N-(C1-6alkyl)2amino;
- m is 1, 2 or 3;
- and
- q is 0, 1, 2, 3 or 4;
- or a pharmaceutically acceptable salt or an in vivo cleavable ester thereof;
- with the proviso that:
- 4-(3-acetamidoanilino)-6,7-dimethoxyquinazoline;
- and 4-(3-benzamidoanilino)-6,7-dimethoxyquinazoline are excluded.