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AssigneeSchering Corporation
InventorsDetlef Grawe, Hagen Gerecke, Peter Hoesel, Annette Eichardt, Sabine Gliesing, Uwe Mueller
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The process for making steroid crystals having a predetermined average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, includes subjecting a supersaturated solution containing a steroid to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described.
A process for making steroid crystals, said steroid crystals having an average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, said process comprising subjecting a supersaturated solution containing a steroid to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension.
Steroid crystals having an average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, wherein said steroid crystals are made by a process comprising subjecting a supersaturated solution containing a steroid to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension.
A pharmaceutical preparation containing steroid crystals, said steroid crystals having an average particle size and a maximum particle size, wherein said steroid crystals are made by a process comprising subjecting a supersaturated solution containing a steroid to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension.
Dependencies are inferred from the claim text.