Gene sequences associated with neural plasticity and methods related thereto
AssigneeMax Cynader
InventorsMax Cynader, Shiv Prasad
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Abstract
The disclosed invention generally relates to newly identified polynucleotide sequences capable of conferring neural plasticity to neurons. Additionally, this application encompasses the complete gene sequences, the polypeptides associated therewith, and methods of using. These methods include the use of the sequences for gene therapy, including the treatment or cure of genetic diseases, for the treatment of degenerative disorders, for the treatment of neuron damage, and for the treatment of learning disorders. Additionally, these sequences are useful to enhance memory and learning capacity.
Claims56
A cDNA library, comprising polynucleotides isolated from a visual cortex of a kitten about 24-35 days old.
A cDNA library, comprising polynucleotides differentially expressed between polynucleotides isolated from a visual cortex of a kitten about 24-35 days and polynucleotides isolated from a visual cortex of an adult feline.
A cDNA library, comprising polynucleotides differentially expressed between polynucleotides isolated from a visual cortex of a dark-reared adult feline and polynucleotides of a visual cortex of an adult feline.
A cDNA library, comprising polynucleotides isolated from the visual cortex of a dark-reared adult feline.
A composition comprising an isolated polynucleotide having a sequence designated as one of:
- Seq. id. nos.:
- 1-132
- or allelic variation thereof or complementary sequence thereto, or portion thereof at least 15 nucleotides in length.
A composition comprising an isolated cDNA displaying at least 90% homology with the coding region of a polynucleotide corresponding to a sequence designated as one of:
- SEQ. ID. NOS.:
- 1-132.
A composition comprising a human gene, said gene being capable of hybridizing to a sequence designated as any one of SEQ. ID. NOS.:
- 1-93, 120-132, or to a sequence complementary thereto, under hybridization conditions sufficiently stringent to require at least about 80% base pairing.
A composition, comprising a peptide of at least about 10 amino acids in length encoded by a sequence designated as one of:
- SEQ. ID. NOS.:
- 1-93 and 127-132.
A composition, comprising a recombinant binding partner capable of specifically binding a gene product encoded by the coded sequence designated as one of:
- SEQ. ID. NOS.:
- 1-132
- or a sequence complementary thereto.
Dependencies are inferred from the claim text.