Peptides for recognition and targeting of GLIAL cell tumors
AssigneeAuburn University
InventorsTatiana I. Samoylova, Valery A. Petrenko, Nancy R. Cox, Nancy E. Morrison, Henry J. Baker, Ludmila P. Globa
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Abstract
Compositions for use in characterization, diagnosis, prognosis, and therapy of cancer cells are provided. The compositions comprise peptides and variants thereof which were isolated based on their ability to selectively bind glioma cells.
Claims20
A synthetic peptide containing the motif E(L/V/S)RGDS, wherein said synthetic peptide exhibits preferential binding to RG2 glioma cells when compared to its binding to astrocytes.
A synthetic peptide containing the motif D(T/S/L/M)TK, wherein said synthetic peptide exhibits preferential binding to RG2 glioma cells when compared to its binding to astrocytes.
A synthetic peptide containing the motif V(D/G)LP(E/T)H, wherein said synthetic peptide exhibits binding to RG2 glioma cells.
Dependencies are inferred from the claim text.