Vasostatin as marrow protectant
AssigneesThe Government of the United States of America, represented by the Secretary of Health and Human Services
InventorsGiovanna Tosato, Sandra E. Pike, Lei Yao
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Abstract
Specific fragments of vasostatin are disclosed. Also disclosed is a method of stimulating the proliferation or survival of a hematopoietic cell exposed to a chemotherapeutic agent or irradiation using these fragments. A method of stimulating the proliferation or survival of a hematopoietic cell is also disclosed. In one embodiment, the method is disclosed for stimulating the growth or survival of a hematopoietic stem cell with a fragment of vasostatin, in the presence of a growth factor.
Claims49
A peptide consisting essentially of at least 18 consecutive amino acids of SEQ ID NO:3.
A method for stimulating the proliferation of a hematopoietic cell in a subject exposed to a chemotherapeutic agent or irradiation comprising
- contacting the cell with a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3, thereby stimulating the proliferation of the hematopoietic cell in the subject.
A method for stimulating the growth of a hematopoietic stem cell, comprising
- contacting the cell with a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3 and a growth factor, thereby stimulating the proliferation or survival of the hematopoietic cell.
A method of stimulating the proliferation or survival of a hematopoietic stem cell in a subject, comprising
- administering to the subject a therapeutically effective amount of a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3, thereby stimulating the proliferation or survival of the hematopoietic stem cell.
A method of protecting a bone marrow cell in a subject treated with a chemotherapeutic agent or radiation from toxicity caused by chemotherapy or irradiation, comprising administering to the subject a therapeutically effective amount a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3, thereby stimulating the protecting the bone marrow cell from the toxicity caused by chemotherapy or irradiation.
A method of protecting a bone marrow cell in a subject treated with a chemotherapeutic agent or radiation from toxicity caused by chemotherapy or irradiation, comprising administering to the subject a therapeutically effective amount of a nucleic acid encoding a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3, thereby stimulating the protecting the bone marrow cell from the toxicity caused by chemotherapy or irradiation.
A method of stimulating hematopoiesis in a subject with a disorder that impairs hematopoiesis, comprising administering to the subject a therapeutically effective amount of a peptide comprising at least 18 consecutive amino acids of SEQ ID NO:3, thereby treating the disorder that impairs hematopoiesis.
Dependencies are inferred from the claim text.