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US 2003/0215836 A1Published application
Bone morphogenic protein polynucleotides, polypeptides, and antibodies
OwnerPaul E. Young, Steven M. Rubeninventors
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Abstract
The present invention relates to novel human BMP polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human BMP polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human BMP polypeptides.
Claims41
An isolated polypeptide comprising a first amino acid sequence at least 90% identical to a second aminon acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:4 or the polypeptide encoded by cDNA HLDOU18;
- (b) the amino acid sequence of amino acids 23 to 429 of SEQ ID NO:4 or the mature polypeptide encoded by cDNA HLDOU18;
- (c) the amino acid sequence of amino acids 23 to 319 of SEQ ID NO:4;
- (d) the amino acid sequence of amino acids 23 to 327 of SEQ ID NO:4
- (e) the amino acid sequence of amino acids 320 to 429 of SEQ ID NO:4;
- and
- (f) the amino acid sequence of amino acids 327 to 429 of SEQ ID NO:4.
4 more elements
Dependencies are inferred from the claim text.