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US 2003/0215829 A1Published application
Nuclear hormone receptors
OwnerAnna M. Chinn, Yan Lu +1inventors
InventorsAnna M. Chinn, Yan Lu, Catherine M. Tribouley
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Abstract
The invention provides human nuclear hormone receptors (NHREC) and polynucleotides which identify and encode NHREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NHREC.
Claims56
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1,
- b) a naturally occurring polypeptide comprising an amino acid sequence at least 99% identical to the amino acid sequence of SEQ ID NO:1,
- c) a biologically active fragment of a polypeptide having the amino acid sequence of SEQ ID NO:1, and
- d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:1.
1 more element
An isolated polynucleotide selected from the group consisting of:
- a) a polynucleotide comprising the polynucleotide sequence of SEQ ID NO:2,
- b) a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to the polynucleotide sequence of SEQ ID NO:2,
- c) a polynucleotide complementary to the polynucleotide of a),
- d) a polynucleotide complementary to the polynucleotide of b), and
- e) an RNA equivalent of a)-d).
2 more elements
A method of making a monoclonal antibody with the specificity of the antibody of claim comprising:
- a) immunizing an animal with a polypeptide having the amino acid sequence of SEQ ID NO:1, or an immunogenic fragment thereof, under conditions to elicit an antibody response;
- b) isolating antibody producing cells from the animal;
- c) fusing the antibody producing cells with immortalized cells to form monoclonal antibody-producing hybridoma cells;
- d) culturing the hybridoma cells;
- and
- e) isolating from the culture monoclonal antibody which binds specifically to a polypeptide having the amino acid sequence of SEQ ID NO:1.
3 more elements
Dependencies are inferred from the claim text.