Gene markers for lung cancer
AssigneesHitachi Chemical Research Center, Inc., Hitachi Chemical Company, Ltd.
InventorsMasato Mitsuhashi, Hiroko Matsunaga, Hideki Kambara, Masafumi Kawamura
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Abstract
A method for the diagnosis and identification of new or residual lung cancer is disclosed which uses newly identified markers for lung cancer including syndecan 1, collagen 1 alpha 2, and two novel proteins, 7013 and 7018. The method involves identification of the lung cancer markers is blood from a patient. It is envisioned that at least one marker may be used or any mixture of the four. The method may also include the identification of cytokeratin-19.
Claims19
A method for the identification of lung cancer comprising:
- isolating blood or non-lung tissue from a patient,
- identifying the presence of at least one marker selected from the group consisting of syndecan 1, collagen 1 alpha 2, 7013, and 7018.
A method for the isolation or removal of metastatic cancer cells, comprising:
- treating cells or a non-lung tissue containing cancer cells with antibodies specific for at least one marker selected from the group consisting of:
- syndecan 1, collagen 1 alpha 2, 7013, and 7018.
A polynucleotide comprising at least 17 nucleotides of SEQ ID NO:
- 16 (p7013, ATCC accession No. ______, Jun. 21, 2001).
A polynucleotide comprising at least 17 nucleotides of SEQ ID NO:
- 17 (p7018. ATCC accession No. ______, Jun. 21, 2001).
A polynucleotide comprising at least 17 nucleotides of p7013112, ATCC accession No. ______, Jun. 21, 2001.
A method for the identification of metastases of a solid tumor in a patient, comprising:
- isolating blood or bone marrow from said patient;
- and
- identifying the presence of at least one marker selected from the group consisting of:
- syndecan 1, collagen 1 alpha 2, 7013, and 7018.
A method for the identification of a carcinoma, comprising:
- obtaining a cancer cell;
- and
- identifying the presence of the markers selected from the group consisting of:
- 7013, 7018, and both.
Dependencies are inferred from the claim text.