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US 2003/0215810 A1Published application
Simple catalytic DNA biosensors for ions based on color changes
AssigneeThe Board of Trustees of the University of Illinois
InventorsYi Lu, Juewen Liu
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Abstract
Disclosed are compositions and methods for the sensitive and selective detection of ions using nucleic acid enzymes and DNA modified microparticles.
Claims36
A method of detecting the presence of an ion, comprising:
- (a) forming a mixture comprising an aggregate and a sample;
- and
- (b) detecting deaggregation of the aggregate;
- wherein the aggregate comprises a nucleic acid enzyme, a substrate and particles, the nucleic acid enzyme is dependent on the ion to cause cleavage of the substrate, and the substrate comprises nucleotides.
1 more element
A composition comprising a nucleic acid enzyme, a substrate and particles, wherein the nucleic acid enzyme is dependent on an ion to cause cleavage of the substrate, and the substrate comprises nucleotides.
A kit for detecting an ion, comprising:
- (a) a cleavable substrate;
- (b) particles;
- and
- (c) a nucleic acid enzyme,
- wherein, the nucleic acid enzyme is dependent on the ion to cause cleavage of the substrate, and the substrate comprises nucleotides.
2 more elements
Dependencies are inferred from the claim text.