US 2003/0215792 A1 · Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least on neuropeptide

Abstract

The invention concerns a nucleic acid molecule which includes a nucleic acid sequence coding for a chemokine, a neuropeptide precursor or at least one neuropeptide, as well as a host cell which contains this nucleic acid molecule. In addition the invention concerns a polypeptide molecule which functions as chemokine or neuropeptide or contains at least one neuropeptide, as well as fragments thereof which include at least one neuropeptide, and a procedure for the manufacture of the polypeptide molecule or of a fragment thereof. In addition the invention concerns antibodies, demonstration procedures and test-kits as well as pharmaceutical preparations. The purpose on which present invention is based is to make new means available which can be put to use aimed at the diagnosis and/or treatment of diseases which are associated with a defect of the SDF-1 factor or its receptor (CXCR4).

Claims35

Dependent claims

Nucleic acid molecule with a sequence comprising

(1) nucleic acid sequence coding for a chemokine, a neuropeptide precursor or at least one neuropeptide, which is selected from the following sequences:
(a) a nucleic acid sequence agreeing with SEQ ID NO:
1;
(b) a nucleic acid sequence which codes for a polypeptide with an amino-acid sequence agreeing with SEQ ID NO:2;
(c) a nucleic acid sequence which is at least 60% identical with the sequence indicated in (a);
(d) a sequence which hybridizes with the opposing strand of the sequence indicated in (a), or would be hybridized under conditions of degeneration of the genetic code;
(e) a derivative obtained through substitution, addition, inversion and/or deletion of one or more nucleotides of one or more of the sequences indicated in (a) or (b), which codes for a chemokine, a neuropeptide precursor or at least one neuropeptide;
or
(2) a sequence complementary to one of the nucleic acid sequences given under (a) to (e).

6 more elements

Dependencies are inferred from the claim text.

Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least on neuropeptide

Life of this patent

Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least on neuropeptide

Life of this patent

Abstract

Claims35