Preservation of bioactive materials by spray drying
AssigneeMedImmune Vaccines, Inc.
InventorsVu Truong-Le, Binh Pham
Life of this patent
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Abstract
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing bioactive materials.
Claims93
A method of preparing powder particles containing bioactive material, the method comprising:
- preparing a suspension or solution comprising the bioactive material, and a polyol;
- forming a mixture of the solution or suspension with a high pressure gas or near supercritical fluid;
- reducing a pressure on the mixture, thereby forming a gaseous suspension of droplets;
- and,
- drying the droplets into powder particles by exchanging a gas from the gaseous suspension of droplets with a drying gas.
An apparatus for preparation of powder particles containing bioactive materials, the apparatus comprising:
- a first chamber containing a suspension or solution comprising a bioactive material, and a polyol;
- a second chamber containing a high pressure gas or a near supercritical fluid;
- a mixing chamber in fluid communication with the first chamber through a first conduit and in fluid communication with the second chamber through a second conduit;
- a capillary restrictor providing restricted fluid communication between the mixing chamber and a particle formation vessel;
- and,
- a stream of a drying gas;
- whereby the suspension or solution is mixed with the high pressure gas or near supercritical fluid in the mixing chamber and sprayed into the particle formation vessel, thereby forming a fine mist of droplets which is dried by the drying gas, thereby preparing powder particles containing the bioactive material.
A suspension or solution for mixture with a near supercritical fluid to form spray dried powder particles with improved stability, the suspension or solution comprising a bioactive material, a polyol, a polymer, and a surfactant.
An article of manufacture comprising a container containing dried powder particles prepared by spray drying a mixture of near supercritical gas with a suspension or solution of bioactive material, a polyol, a polymer, and a surfactant.
A kit to containing elements of an apparatus for preparation of powder particles according to the methods of preparing dried particle compositions wherein the mtthods comprise:
- preparing a suspension or solution comprising the bioactive material, and a polyol;
- forming a mixture of the solution or suspension with a high pressure gas or near supercritical fluid;
- reducing a pressure on the mixture, thereby forming a gaseous suspension of droplets;
- and,
- drying the droplets into powder particles by exchanging a gas from the gaseous suspension of droplets with a drying gas.
Dependencies are inferred from the claim text.