Chemosensitizing with liposomes containing oligonucleotides
AssigneeGeorgetown University
InventorsUsha Kasid, Prafulla Gokhale, Jin Pei, Rajshree Mewani, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of oliognucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to chemosensitize cancer are tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treatment of ras expressing tumors such as breast, lung, pancreatic and prostate cancer.
Claims22
A method of chemosensitization of tumor tissue comprising administration of a chemotherapeutic agent and a composition comprising cationic liposomes which consists of cationic lipid, phosphatidylcholine and cholesterol and having encapsulated therein at least one oligonucleotide.
A composition of matter comprising liposomes consisting essentially of a cationic lipid like dimethyldioctadecyl ammonium bromide (DDAB), phosphatidylcholine (PC), and cholesterol, and containing the sequence 5′-GTGCTCCATTGATGC-3′ (Seq. ID No:
- 1) wherein only the terminal sequences are phosphorothioated.
A composition of matter comprising liposomes consisting essentially of a cationic lipid like dimyristoyl trimethyl ammonium propane (DMTAP), phosphatidylcholine (PC), and cholesterol, and containing the sequence 5′-GTGCTCCATTGATGC-3′ (Seq. ID No:
- 1) wherein only the terminal sequences are phosphorothioated.
Dependencies are inferred from the claim text.