Liquid permeable composition in dry reagent devices
OwnerLloyd S. Schulman, Michael J. Pugia +2inventors
InventorsLloyd S. Schulman, Michael J. Pugia, Karlheinz Hildenbrand, Spencer H. Lin
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Abstract
A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.
Claims67
A device for detection of an analyte in a liquid sample comprising a liquid permeable layer capable of adhesion, said layer comprising a blend of an aqueous polymer dispersion and a water soluble polymer which has been dried to form said liquid permeable layer, said liquid permeable layer being disposed between absorbent or non-absorbent layers for transferring portions of said liquid sample.
A method of analyzing a liquid sample wherein said sample is contacted with dry reagents in layers which react with analytes in said sample to provide a detectable response characterized by including a liquid permeable layer capable of adhesion between said layers, said liquid permeable layer transferring portions of said liquid sample.
A multi-layer device for detection of an analyte in a fluid sample comprising:
- (a) at least a first absorbent or non-absorbent layer for receiving said fluid sample;
- (b) at least a second absorbent or non-absorbent layer for receiving a portion of said sample from said first layer;
- and
- (c) a liquid permeable adhesive layer disposed between said first and second layers, said adhesive being diffusable to fluids and comprising a blend of an aqueous polymer dispersion and a water soluble polymer which has been cast and dried to form said adhesive layer.
A microfluidic device for detection of an analyte in a liquid sample comprising:
- (a) at least one well for receiving said sample;
- (b) at least one well containing a dry reagent for receiving at least a portion of said sample and reacting with said analyte;
- (c) a capillary passageway in liquid communication with said wells of (a) and (b);
- wherein said device includes a liquid permeable composition comprising a blend of an aqueous polymer dispersion and a water soluble polymer which has been dried to form said liquid permeable composition, said composition disposed in at least one of said wells to remove or react with components of said liquid sample.
Dependencies are inferred from the claim text.