Remedies for inflammatory bowel diseases

Prophylactic and/or therapeutic drugs against ulcerative colitis, which include five-member heterocyclic compounds represented by the formula (I) or these nontoxic salts as active principle,

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• (wherein Z represents the group to contain x-aminocarbonyl group that carbonyl carbon atom combines with carbon atom of heterocyclic group through covalent bond,
• R1 represents (1) alkyl, alkenyl or alkynyl groups, with the proviso that these groups may be substituted with one or more groups chosen from (a) halogen atom, (b) hydroxy, (c) cyano, (d) nitro, (e) haloalkyl, (f) alkylamino, (g) dialkylamino (h) alkoxy, (i) haloalkoxy, (j) carboxy, (k) carboalkoxy, (l) alkylcaroxamide, (m) arylcaroxamide or (n) —O—(C5-C6) aryl groups,
• (2) hydroxy,
• (3) amino,
• (4) alkylamino,
• (5) dialkylamino, or
• (6) cycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, cycloalkenyl, alkylcycloalkenyl, alkenylcycloalkenyl, (C5-C12)aryl, (C5-C12)arylalkyl, (C5-C12)arylalkenyl, condensable (C5-C12)aryl-cycloalkyl or alkyl condensable (C5-C12)aryl-cycloalkyl, with the proviso that these groups may be substituted with groups chosen from (a) halogen atom, (b) hydroxy, (c) cyano, (d) nitro, (e) haloalkyl, (f) amino, (g) aminoalkyl, (h) dialkylamino, (i) alkyl, (j) alkenyl, (k) alkylenedioxy, (l) alkynyl, (m) alkoxy, (n) haloalkoxy, (o) carboxy, (p) carboalkoxy, (q) carboxamide, (r) (C5-C6)aryl, (s) —O—(C5-C6)aryl, (t) arylcarboxamide, (u) alkylthio or (v) haloaklylthio that may include 1-4 of hetero atoms chosen from nitrogen, oxygen or sulfur atom, respectively,
• X and Y each independently represent oxygen, sulfur, nitrogen or atom,
• which nitrogen atom may be substituted with groups chosen from
• (1) alkyl or alkenyl that may be substituted with 1-3 of halogen atom,
• (2) alkynyl,
• (3) (C5-C6)aryl, arylalkyl, arylalkenyl that may include 1-3 of hetero atoms chosen from nitrogen, oxygen or sulfur atom or may be substituted with groups chosen from (a) halogen atom, (b) cyano, (c) nitro, (b) hydroxy, (e) haloalkyl, (f) amino, (g) aminoalkyl, (h) dialkylamino, (i) alkyl, (j) alkenyl, (k) alkynyl, (l) alkoxy, (m) haloalkoxy, (n) carboxy, (o) carboalkoxy, (p) carboxamide, (q) arylcarboxamide, (r) alkylthio or (s) haloaklylthio).