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US 2003/0212110 A1Published application
Calcilytic compounds
AssigneeSmithKline Beecham Corporation
InventorsPradip K. Bhatnagar, James F. Callahan, Amparo M. Lago
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Abstract
Novel calcilytic compounds and methods of using them are provided.
Claims11
A compound according to formula (I) hereinbelow:
- 5
- wherein:
- A represents C or N with one or two N in ring I;
- D represents C or N with one or two N in the ring I that is attached at position 4 or 5 to ring I as indicated;
- X is selected from the group consisting of CN, NO2, Cl, F, and H;
- Y is selected when A is C from the group consisting of Cl, F, Br, I and H;
- Q is selected when D is C from the group consisting of H, R1, SO2R1′,
- R1C(O)OR′1, tetrazole, CH2OH, COH, SO2NR1′R1″, C(O)N R1′R1″, and
- NR1SO2R1′, wherein R1 is independently selected from the group consisting of bond, hydrogen, C1-4 alkyl, and optionally substituted alkyl,
- R1′, and R1″ are independently selected from the group consisting of hydrogen, C1-4 alkyl, and optionally substituted alkyl, or R1′, and R1″ together form a 3 to 7 membered optionally substituted heterocyclic ring;
- Ar is phenyl or naphthyl, unsubstituted or substituted, heteroaryl or fused heteroaryl, such that the hetero-ring may contain N, O or S and may be aromatic, dihydro or tetrahydro, unsubstituted or substituted,
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.