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AssigneeMillennium Pharmaceuticals, Inc.
InventorsRuth Gimeno, Bruce M. Spiegelman
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The present invention relates to methods and compositions for the treatment and diagnosis of body weight disorders, including, but not limited to, obesity, overweight, anorexia, cachexia, insulin resistance, and diabetes. The invention further provides methods for identifying a compound capable of treating a body weight disorder or modulating thermogenesis. The invention also provides a method for modulating thermogenesis, e.g., modulating thermogenesis in a subject. In addition, the invention provides a method for treating a subject having a body weight disorder characterized by aberrant DHDR-2 polypeptide activity or aberrant DHDR-2 nucleic acid expression. In another aspect, the invention provides methods for modulating thermogenesis in a subject.
A method for identifying a compound capable of treating a body weight disorder comprising assaying the ability of the compound to modulate DHDR-2 nucleic acid expression or DHDR-2 polypeptide activity, thereby identifying a compound capable of treating a body weight disorder.
A method for identifying a compound capable of modulating thermogenesis comprising:
A method for modulating thermogenesis in a cell comprising contacting a cell with a DHDR-2 modulator, thereby modulating thermogenesis in the cell.
A method for treating a subject having a body weight disorder characterized by aberrant DHDR-2 polypeptide activity or aberrant DHDR-2 nucleic acid expression comprising administering to the subject a DHDR-2 modulator, thereby treating said subject having a body weight disorder.
A method for modulating thermogenesis in a subject comprising administering to the subject a DHDR-2 modulator, thereby modulating thermogenesis in said subject.
Dependencies are inferred from the claim text.