Method and composition for treatment of inflammatory bowel disease
OwnerRaymond J. Bergeron JR.inventor
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Abstract
A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: 1 and a pharmaceutically acceptable carrier therefor. Also disclosed is a method for the inhibition, prevention or treatment of inflammatory bowel disease comprising administering to a human or non-human mammal in need thereof an effective amount of a compound having the formula: 2
Claims17
A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound and a pharmaceutically acceptable carrier therefor, the compound having the formula:
- 5
- wherein:
- Z is CH or N;
- R is H or acyl;
- R1, R2, R3 and R5 may be the same or different and represent H, alkyl or hydrocarbyl arylalkyl having up to 14 carbon atoms;
- and
- R4 is H, alkyl having 1-6 carbon atoms or OR.
A composition in unit dosage form adapted for topical administration to the colon of a human or non-human mammal for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of desferrioxamine B, a homolog or analog thereof and a pharmaceutically acceptable carrier therefor, said desferrioxamine B, homolog or analog thereof having the formula:
- 8
- wherein:
- each n may be the same or different and is an integer from 1-10;
- each m may be the same or different and is an integer from 2-6;
- a and b are integers from 1-6;
- c is an integer from 0-10;
- R is a straight or branched chain alkyl having 1-14 carbon atoms or aryl;
- and
- R1 and R2 are straight or branched chain alkyls having 1-10 carbon atoms.
Dependencies are inferred from the claim text.