Systems and methods to facilitate multiple order combinatorial chemical processes

A method for making a library of constructs, the method comprising:

• providing a set of solid supports that each include at least two sites;
• synthesizing a chemical entity from a chemical library A having A1-Ai chemical entities to one of the sites of each solid support while the other site is blocked;
• unblocking the blocked site for each solid support;
• and
• synthesizing a chemical entity from a chemical library B having B1-Bj chemical entities to the unblocked sites to form a set of constructs that includes essentially every possible pairwise combination of the chemical entities A1-Ai of the chemical library A and the chemical entities B1-Bj of the chemical library B.

A construct comprising:

• a solid support having at least one arm and at least a pair of sites branching from the arm;
• a chemical entity A coupled to one of the sites;
• and
• a chemical entity B coupled to the other site, with the pair of sites being configured such that the chemical entity A is spaced apart from the chemical entity B at a distance selected to facilitate a reaction between the chemical entity A and the chemical entity B.

A method to screen for reactive chemicals, the method comprising:

• configuring a set of constructs such that each construct of the set includes a pairwise combination of a chemical entity A1-Ai of a catalyst library A and a chemical entity B1-Bj of a catalyst library B;
• exposing the constructs to a substrate in solution phase to facilitate potential reactions involving the chemical entity A1-Ai and the chemical entity B1-Bj of each construct;
• screening the constructs to identify any reactions or interactions;
• and
• determining the chemical entity A1-Ai and the chemical entity B1-Bj of any constructs where reactions or interactions occurred.