Bioabsorbable polymer containing 2-hydroxyacid monomers
AssigneesMetabolix, Inc., Tepha, Inc.
InventorsDavid P. Martin, Frank A. Skraly
Life of this patent
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Abstract
Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing 2-hydroxyacid monomers can be synthesized via biosynthesis by the action of a PHA polymerase in a living cell. By changing the genetic background of the cells, one can control specific metabolic pathways allowing control of the level of glycolic acid co-monomer in the PHA polymer.
Claims19
A method of producing 2-hydroxyacid-containing polymer comprising expressing in an organism exogenous genes encoding a polyhydroxyalkanoate (PHA) synthase and at least one enzyme for the production of 2-hydroxyacyl Co-A.
A polymer containing 2-hydroxyacid formed by expressing in an organism exogenous genes encoding a polyhydroxyalkanoate (PHA) synthase and at least one enzyme for the production of 2-hydroxyacyl Co-A.
A genetically engineered organism producing a polyhydroxyalkanoate comprising a 2-hydroxyacid other than 2-hydroxybutyric acid.
A medical device formed of a composition comprising a polymer containing 2-hydroxyacid formed by expressing in an organism exogenous genes encoding a polyhydroxyalkanoate (PHA) synthase and at least one enzyme for the production of 2-hydroxyacyl Co-A.
Dependencies are inferred from the claim text.