Immunogens for treatment of neoplastic and infectious disease
AssigneeApplied Immune Technologies
InventorRaj Tiwari
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Abstract
The present invention relates to prophylactic and therapeutic methods of immunization against neoplastic and infectious diseases. The invention provides a method for identification of novel immunogens and compositions of such immunogens that are useful for eliciting immune responses against antigens associated with neoplastic or infectious diseases.
Claims28
A method of eliciting an immune response against a target cell in a host comprising:
- a) isolating first binding substances that specifically bind to heat shock protein-peptide complexes differentially expressed by the target cell relative to a second cell;
- b) isolating second binding substances that specifically bind to the first binding substances;
- and
- c) immunizing the host with a therapeutically effective amount of the second binding substances.
A method for identifying a mimotope for an antigen expressed by a target cell comprising:
- a) isolating first binding substances that specifically bind to heat shock protein-peptide complexes differentially expressed by the target cell relative to a second cell;
- and
- b) isolating and identifying second binding substances that specifically bind to the first binding substances.
A method of making a vaccine against a target cell or an antigen thereof, comprising:
- a) isolating first binding substances that specifically bind to heat shock protein-peptide complexes differentially expressed by the target cell relative to a second cell;
- b) isolating mimotopes that specifically bind to the first binding substances;
- and
- c) incorporating the mimotopes into the vaccine.
A method of eliciting an immune response against a prostate tumor comprising administering a immunologically effective amount of a peptide selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3 conjugated to a carrier.
Dependencies are inferred from the claim text.