Galectin 11
AssigneesHuman Genome Sciences, Inc., La Jolla Institute for Allergy and Immunology
InventorsJian Ni, Reiner L. Gentz, Craig A. Rosen, Fu-Tong Liu
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Abstract
The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
Claims20
An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 1 to 133 of SEQ ID NO:
- 2;
- (b) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 2 to 133 of SEQ ID NO:
- 2;
- (c) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 1 to 275 of SEQ ID NO:
- 25;
- (d) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 2 to 275 of SEQ ID NO:
- 25;
- (e) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 1 to 296 of SEQ ID NO:
- 27;
- (f) a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding amino acids 2 to 296 of SEQ ID NO:
- 27;
- and
- (g) the complement of (a), (b), (c), (d), (e), or (f).
An isolated galectin 11 polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence which is at least 95% identical to amino acids 1 to 133 of SEQ ID NO:
- 2;
- (b) an amino acid sequence which is at least 95% identical to amino acids 1 to 275 of SEQ ID NO:
- 25;
- (c) an amino acid sequence which is at least 95% identical to amino acids 1 to 296 of SEQ ID NO:
- 27
- (d) amino acids 1 to 121 of SEQ ID NO:
- 25;
- (e) amino acids 1 to 142 of SEQ ID NO:
- 27;
- and
- (f) amino acids 151 to 275 of SEQ ID NO:
- 25.
Dependencies are inferred from the claim text.