Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity

A compound of formula (Ic)

• B—SO2—CH2—CHR1—CO—NHOH (Ic)
• wherein
• R1 is C1-6 alkyl substituted with R9;
• B is aryl or heteroaryl, either of which is optionally substituted by a substituent selected from R5, C1-6 alkyl-R5, C2-6 alkenyl-R5, aryl (optionally substituted with R5), aryl-C1-6 alkyl-R5, C1-6 alkyl-aryl (optionally substituted with R5), C1-6 alkyl-heteroaryl (optionally substituted with R5), aryl-C2-6 alkenyl-R7, heteroaryl (optionally substituted with R5), heteroaryl-C1-6 alkyl-R5, cycloalkyl (optionally substituted with R5), benzofused cycloalkyl (optionally substituted with R5), heterocycloalkyl (optionally substituted with R5), benzofused heterocycloalkyl (optionally substituted with R5), and the groups:
• 15
• R2 is H or C1-6 alkyl;
• R5 is C1-6 alkyl, C2-6 alkenyl-R7, halogen, CN, NO2, N(R6)2, OR6, COR6, CO2R2, CON(R6)2, NR6R7, S(O)0-2R8 or SO2N(R6)2;
• R6 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl and C1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R8, COR8, SO0-2R8, CO2R8, OR8, CONR2R8, NR2R8, halogen, CN, SO2NR2R8 or NO2, and for each case of N(R6)2 the R6 groups are the same or different or N(R6)2 is heterocycloalkyl optionally substituted with R8, COR8, SO0-2R8, CO2R8, OR8, CONR2R8, NR2R8, halogen, CN, SO2NR2R8 or NO2;
• R7 is COR6, CON(R6)2, CO2R8 or SO2R8;
• R8 is C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl;
• and
• R9 is phthalimido, succinimido or the group:
• 16
• or an N-oxide, salt, solvate, hydrate, protected amino or protected carboxy derivative thereof.