US 2003/0207801 A1 · Novel polypeptides and nucleic acids encoding same

Novel polypeptides and nucleic acids encoding same

OwnerValerie Gerlach, John R. MacDougall +12inventors

InventorsValerie Gerlach, John R. MacDougall, Isabelle Millet, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook II, Denise M. Lepley, Catherine E. Burgess, Corine A. M. Vernet, Suresh G. Shenoy, Kimberly Ann Spytek, Vishnu S. Mishra, Muralidhara Padigaru

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Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims49

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature formn of an amino acid sequence selected from the group consisting of SEQ ID NO:
2;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting SEQ ID NO:
2;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

6 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NO:
2;
(d) a variant of an amino acid sequence selected from the group consisting SEQ ID NO:
2, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NO:
2, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/035,568Filed 22 Oct 2001

Priority

23 Oct 2000

Published

6 Nov 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07K 14/47
From vertebrates: from mammals
A61K 38/00
Medicinal preparations containing peptides
A61K 39/00
Medicinal preparations containing antigens or antibodies
C07K
Peptides

Family

Application60/242,485Us provisional application · filed 23 Oct 2000

Application60/263,339Us provisional application · filed 22 Jan 2001

Application60/264,850Us provisional application · filed 29 Jan 2001

US 2003/0207801 A1This patent

From the US filing history. Foreign family members aren’t listed.