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AssigneeRoche Diagnostics Operations, Inc.
InventorsMitali Ghoshal, Gerald Sigler, Raymond A. Hui, Ronald Hawley, Eva Hoess, Erasmus J. Huber, John W. Patterson, Salvatore J. Salamone, Allan Dorn
Estimating the term…
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
The compound L-thyroxine-5′-isoprenyl-MPA.
The compound 5′-[(digoxigenin-3-yl)-β-amidomethyl-MPA.
The compound 4′-[(digoxigenin-3-yl)-oxymethylcarbonyl-DADOO-carbonylmethyl-MPA.
The compound 5′-[(digoxigenin-3-yl)-oxymethylcarbonyl-DADOO-carbonylmethyl-MPA.
The compound 5′-[(theophylline-8-butyramidoethylaminocarbonyloxy)isoprenyl]-MPA.
A conjugate of a drug or drug derivative and an uncompetitive inhibitor of IMPDH.
A conjugate of a hormone and an uncompetitive inhibitor of IMPDH.
A conjugate of a nucleotide and an uncompetitive inhibitor of IMPDH.
A conjugate of a polypeptide and an uncompetitive inhibitor of IMPDH.
A ligand-inhibitor conjugate with the structure
A ligand-inhibitor conjugate with the structure
A ligand-inhibitor conjugate with the structure
A ligand-inhibitor with the structure
Dependencies are inferred from the claim text.