Cbp86, a sperm specific protein

A nucleic acid sequence comprising the sequence of SEQ ID NO:

• 1, SEQ ID NO:
• 25 or SEQ ID NO:
• 26.

A nucleic acid sequence that hybridizes to a 100 nucleotide fragment of SEQ ID NO:

• 1 under stringent conditions.

A nucleic acid sequence comprising a 25 bp nucleic acid sequence that is identical to a contiguous 25 bp sequence of SEQ ID NO:

• 1.

A method of screening for potential human therapeutic agents, said method comprising contacting a CBP86 protein with a candidate compound;

• and determining if the candidate compound selectively binds to the CBP86 protein.

An antibody that binds specifically to the protein of SEQ ID NO:

• 2.

An antibody that binds specifically to the protein of SEQ ID NO:

• 15.

An antibody that binds specifically to the protein of SEQ ID NO:

• 16.

A method for measuring the capacitation of sperm in a sample wherein said sample comprises sperm cells containing an 86 kDa isoform of CBP86, said method comprising the step of

• measuring the phosphorylation of the 86 kDa isoform.

A method for measuring the capacitation of sperm in a sample wherein said sample comprises sperm cells containing an 86 kDa isoform of CBP86, said method comprising the step of

• measuring the formation of the 86 kDa isoform of CBP86 relative to other isoforms of CBP86.