GPCR-like retinoic acid-induced gene 1 protein and nucleic acid
OwnerDavid A. Lewin, Timothy A. Stewartinventors
Life of this patent
Estimating the term…
Abstract
A novel G-protein coupled receptor-like retinoic acid induced molecule was identified as being differentially expressed (GPCR-like RAIG1) in an animal model of fasting and feeding. Compositions and methods pertaining to treatment and diagnosis of various metabolic disorders, such as cachexia and obesity.
Claims53
An isolated polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence of SEQ ID NO:2.
An isolated polynucleotide comprising a polynucleotide sequence having at least 80% sequence identity to the sequence of SEQ ID NO:1, or a complement of the polynucleotide.
A method of treating metabolic disorders comprising modulating the activity of a polypeptide having at least 80% sequence identity to the sequence of SEQ ID NO:1 or 3.
A method of detecting a disorder associated with changes in GPCR-like RAIG1 gene expression comprising:
- detecting a change in expression or activity of GPCR-like RAIG1 polypeptide.
A method for determining whether a compound up-regulates or down-regulates the transcription of a GPCR-like RAIG1 gene, comprising:
- contacting the compound with a composition comprising a RNA polymerase and the gene and measuring the amount of GPCR-like RAIG1 gene transcription.
A method for determining whether a compound up-regulates or down-regulates the translation of a GPCR-like RAIG1 gene, comprising:
- contacting the compound with a composition comprising a ribosome and a polynucleotide corresponding to a mRNA of the gene and measuring the amount of GPCR-like RAIG1 gene translation.
A transgenic non-human animal, comprising a disrupted GPCR-like RAIG1 gene.
A method of screening a sample for a GPCR-like RAIG1 mutation, comprising:
- comparing a GPCR-like RAIG1 polynucleotide sequence in the sample with SEQ ID NO:1 or SEQ ID NO:3.
A method of treating a metabolic disorder, comprising:
- administering an antagonist or agonist to GPCR-like RAIG1.
Dependencies are inferred from the claim text.