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US 2003/0206908 A1Published application
Human paris-1 antigen and nucleic acids: diagnostic and therapeutic uses
AssigneeNorthwest Biotherapeutics, Inc.
InventorYaling Zhou
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AssigneeNorthwest Biotherapeutics, Inc.
InventorYaling Zhou
Estimating the term…
The present invention relates to the discovery, identification and characterization of a novel tumor suppressor gene designated PARIS-1. The invention includes nucleotide sequences of the PARIS-1 gene and amino acid sequences of its encoded protein product(s), as well as fragments, derivatives and analogs thereof. The invention also includes the production of PARIS-1 proteins, fragments and derivatives and of antibodies specific for PARIS-1 gene products. The invention further comprises agents and compositions which can modulate the expression of PARIS-1 or PARIS-1 expression products to effect the proliferation of cells which express PARIS-1. One particular embodiment comprises agents and compounds which can slow or ablate the proliferation of prostate tumor cells.
An isolated nucleic acid hybridizable under moderate stringency conditions to the nucleotide sequence comprising the nucleotide sequence as depicted in Table 1 and SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a fragment of the PARIS-1 protein that displays one or more functional activities of the PARIS-1 protein.
An antibody which can immunospecifically bind a PARIS-1 protein or fragment thereof.
A composition comprising an amount of PARIS-1 protein, or a fragment thereof, which can effectively modulate cell proliferation and a pharmaceutically acceptable carrier.
A composition comprising an amount of an antigen binding fragment or derivative of an antibody inmmunospecific for PARIS-1 protein and a pharmaceutically acceptable carrier.
A method for decreasing the rate of proliferation of a cell which expresses PARIS-1 in a subject comprising administering an amount of an agent which effectively modulates PARIS-1 activity to modulate cell proliferation.
Dependencies are inferred from the claim text.