Catheter composition and uses thereof
AssigneeGenentech, Inc.
InventorCharles P. Semba
Life of this patent
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Abstract
A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
Claims24
A composition useful for removal of fibrin-bound blood clots from a catheter comprising water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol, wherein the composition does not comprise a chelating agent.
A multi-compartment package comprising a compartment comprising a fibrinolytically effective amount of a plasminogen activator, a compartment comprising water containing a preservatively effective amount of a bacteriostatic organic alcohol, wherein neither compartment comprises a chelating agent, and instructions for mixing the contents of both compartments and for using the resulting mixture to remove fibrin-bound blood clots from a catheter that contains such blood clots.
A multi-compartment package comprising a compartment comprising from about 0.1 to 10 mg/mL of native-sequence t-PA or tenecteplase and a compartment comprising water containing from about 0.5 to 1.2% (v/v) of benzyl alcohol, isopropanol, or ethanol, wherein neither compartment comprises a chelating agent, and instructions for mixing the contents of both compartments and for using the resulting mixture to remove fibrin-bound blood clots from a catheter that contains such blood clots.
Dependencies are inferred from the claim text.