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US 2003/0203473 A1Published application
Microbial SUMO protease homologs
AssigneeSanford-Burnham Medical Research Institute
InventorsAdam Godzik, John C. Reed
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AssigneeSanford-Burnham Medical Research Institute
InventorsAdam Godzik, John C. Reed
Estimating the term…
The invention provides isolated SUMO-specific protease-like (or “SSP”) domain-containing polypeptides from microorganisms, including bacteria, protozoans and yeast, including Eschericia, Salmonella, Pseudomonas, Chlamydia, Plasmodium, Trypanosma, Mesorhizobium, Rickettsia, Cryptosporidium and Candida species, as well as modifications of such polypeptides, functional fragments therefrom, encoding nucleic acid molecules and specific antibodies. Also provided are methods for identifying polypeptides and compounds that associate with or modulate the activity of the SSP domain-containing polypeptides. Further provided are methods of modulating a biological activity in a cell, and treating pathological conditions, using the described nucleic acid molecules, polypeptides and compounds.
An isolated nucleic acid molecule encoding a polypeptide comprising a SUMO-specific protease-like domain (SSP domain), selected from the group consisting of:
An isolated oligonucleotide comprising at least 17 contiguous nucleotides of the SSP-domain encoding portion of SEQ ID NOS:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 40 or 43, or the complement thereof.
An isolated polypeptide comprising a SSP domain, wherein said polypeptide comprises the amino acid sequence designated SEQ ID NOS:27-39, 42 or 45, or modification thereof comprising an amino acid sequence at least 80% identical thereto.
An isolated peptide comprising at least 8 contiguous amino acids of the amino acid sequence set forth as SEQ ID NOS:27-39, 42 or 45.
Dependencies are inferred from the claim text.