Novel neurotrophic factor immunoassays
AssigneeGenentech, Inc.
InventorArnon Rosenthal
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Abstract
A novel polypeptide designated neurotrophic factory (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4β, NT-4γ, and NT-4Δ. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
Claims25
An isolated nucleic acid encoding NT-4.
A composition comprising NT-4 from an animal species, which composition is free of contaminating polypeptides of that animal species.
A nucleic acid that hybridizes to DNA encoding NT-4 under stringent conditions, excluding nucleic acid encoding NGF SDNF or NT-3.
A composition comprising NT-4 linked to an immunogenic polypeptide or a non-proteinaceous polymer.
A pharmaceutical composition comprising an effective amount of NT-4 in a pharmaceutically acceptable carrier.
An antibody that is capable of binding NT-4, but that is norcapable of binding NGF, BDNF or NT-3.
A monoclonal antibody capable of binding NT-4.
A method for treating a neurodegenerative disease or damaged nerve cells comprising administering to a mammal an effective amount of NT-4.
An isolated nucleic acid encoding neurotrophic factor 4 (NT-4) having the amino acid sequence depicted in any one of FIGS. 1, 3, 4 and 5.
Dependencies are inferred from the claim text.