Growth-related inflammatory and immune response protein
OwnerY. Tom Tang, Michael G. Walkerinventors
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Abstract
The invention provides a mammalian cDNA which encodes a mammalian GRIIP. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of disorders associated with inflammation and immune response, particularly cancers of the immune system. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Claims20
An isolated cDNA encoding a protein having the amino acid sequence of SEQ ID NO:
- 1.
An isolated cDNA selected from:
- a) a nucleic acid sequence of SEQ ID NO:2 or the complement thereof;
- b) a fragment of SEQ ID NO:2 selected from SEQ ID NOs:3-10 or the complement thereof;
- and
- c) a variant of SEQ ID NO:2 selected from SEQ ID NOs:11-13.
A purified protein or a portion thereof selected from:
- a) an amino acid sequence of SEQ ID NO:1;
- b) an antigenic epitope of SEQ ID NO:
- 1;
- and
- c) a biologically active portion of SEQ ID NO:1.
Dependencies are inferred from the claim text.