In a pattern to be microlithographically transferred from a reticle to a substrate using a charged particle beam, a method for determining respective configurations of elements of the pattern as defined on the reticle so as to reduce proximity effects on the pattern elements as the pattern elements are transferred to the substrate, the method comprising:
- dividing the pattern, as defined on the reticle, into multiple subregions each containing one or more respective pattern elements;
- for each subregion, determining a respective bias to be applied to the one or more respective pattern elements in the subregion to reduce a proximity effect that otherwise would be manifest when the subregion is transferred to the substrate;
- and
- applying the determined respective bias to the respective one or more pattern elements in each subregion, so as to reconfigure the respective pattern elements, as defined on the reticle, in each subregion in which bias is applied.