US 2003/0083307 A1Published application

Anti-HCV nucleoside derivatives

AssigneeHoffmann-La Roche Inc.

InventorsRene Robert Devos, Christopher John Hobbs, Wen-Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera

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Abstract

The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known 2′-deoxy-2′-fluoro nucleoside derivatives as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds. The compounds of this invention have potential use as therapeutic agents for the treatment of HCV infections.

Claims5

Dependent claims

A method for the treatment of hepatitis C virus (HCV) infection comprising administering a therapeutically effective amount of a compound of formula I

15
wherein
R1 is hydrogen or phosphate and
B is a 1-pyrimidinyl or 9-purinyl residue of formulae B1, B2 or B3
16
and pharmaceutically acceptable salts thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/106,970Filed 26 Mar 2002
Priority: GB 0112617.623 May 2001
Published: 1 May 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/7076
Containing condensed or non-condensed pyrimidines: containing purines, e.g. adenosine, adenylic acid
A61K 31/7068
Containing condensed or non-condensed pyrimidines: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 31/708
Containing purines, e.g. adenosine, adenylic acid: having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…

Family

US 6,660,721 B2Related patent
US 2003/0083307 A1This patent

From the US filing history. Foreign family members aren’t listed.

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