Methods and compositions for treating inflammatory disorders
AssigneePraecis Pharmaceuticals, Inc.
InventorsGerhard Hannig, Douglas Lazarus
Life of this patent
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Abstract
The present invention provides methods and compositions for treating inflammatory disorders, e.g., asthma, lung inflammation or cancer.
Claims38
A method for treating an inflammatory disorder in a subject comprising administering to a subject a polybasic peptide comprising 25 or fewer amino acid residues in an amount effective to treat an inflammatory disorder.
A method for treating an inflammatory disorder in a subject comprising administering to a subject a polybasic peptide having the structure:
- B1—X1—X2—X3—B2—X4—X5—B3,
- wherein B1, B2 and B3 are each, independently, a basic amino acid residue and X1, X2, X3, X4 and X5 are each, independently, an alpha-helix promoting amino acid residue, in an amount effective to treat an inflammatory disorder.
A method for treating an inflammatory disorder in a subject comprising administering to a subject a polybasic peptide having the structure:
- B1—X1—X2—B2—B3—X3—X4—B4,
- wherein B1, B2, B3 and B4 are each, independently, a basic amino acid residue and X1, X2, X3 and X4 are each, independently, an alpha-helix promoting amino acid residue, in an amount effective to treat an inflammatory disorder.
A method for treating an inflammatory disorder in a subject comprising administering to a subject a polybasic peptide having a structure selected from the group consisting of:
- DRQIKIWFQNRRMKWKK (SEQ ID NO:1);
- RQIKIWFQNRRMKWKK (SEQ ID NO:2);
- QIKIWFQNRRMKWKK (SEQ ID NO:3);
- IKIWFQNRRMKWKK (SEQ ID NO:4);
- KIWFQNRRMKWKK (SEQ ID NO:5);
- IWFQNRRMKWKK (SEQ ID NO:6);
- WFQNRRMKWKK (SEQ ID NO:7);
- FQNRRMKWKK (SEQ ID NO:8);
- QNRRMKWKK (SEQ ID NO:9);
- NRRMKWKK (SEQ ID NO:10);
- RRMKWKK (SEQ ID NO:11);
- FKSGLKYKK (SEQ ID NO:12);
- KSGLKYKK (SEQ ID NO:13);
- QRLFQVKGRR (SEQ ID NO:14);
- RLFQVKGRR (SEQ ID NO:15);
- YGRKKRRQRRRP (SEQ ID NO:16);
- GRKKRRQRRRP (SEQ ID NO:17);
- RKKRRQRRRP (SEQ ID NO:18);
- RKKRRQRRRPGG (SEQ ID NO:19);
- AGRKKRRQARR (SEQ ID NO:20);
- YARKARRQARR (SEQ ID NO:21);
- YARAAARQARA (SEQ ID NO:22);
- YARAARRAARR (SEQ ID NO:23);
- YARAARRAARA (SEQ ID NO:24);
- YARRRRRRRRR (SEQ ID NO:25);
- RKKRRQRRR (SEQ ID NO:26);
- RKKRRQRR (SEQ ID NO:27);
- YGRKKRRQRRR (SEQ ID NO:28);
- YGRKKRRQRR (SEQ ID NO:29);
- GRKKRRQRRR (SEQ ID NO:30);
- GRKKRRQRR (SEQ ID NO:31);
- RRRRR (SEQ ID NO:32);
- RRRRRR (SEQ ID NO:33);
- RRRRRRR (SEQ ID NO:34);
- RRRRRRRR (SEQ ID NO:35);
- RRRRRRRRR (SEQ ID NO:36);
- RRRRRRRRRR (SEQ ID NO:37);
- RRRRRRRRRRR (SEQ ID NO:38);
- and RRRRRRRRRRRR (SEQ ID NO:39), in an amount effective to treat an inflammatory disorder.
An anti-inflammatory compound having the structure:
- B1—X1—X2—X3—B2—X4—X5—B3,
- wherein B1, B2 and B3 are each, independently, a basic amino acid residue and X1, X2, X3, X4 and X5 are each, independently, an alpha-helix promoting amino acid residue.
An anti-inflammatory compound having the structure:
- B1—X1—X2—B2—B3—X3—X4—B4,
- wherein B1, B2, B3 and B4 are each, independently, a basic amino acid residue and X1, X2, X3 and X4 are each, independently, an alpha-helix promoting amino acid residue.
An anti-inflammatory compound having a structure selected from the group consisting of:
- DRQIKIWFQNRRMKWKK (SEQ ID NO:1);
- RQIKIWFQNRRMKWKK (SEQ ID NO:2);
- QIKIWFQNRRMKWKK (SEQ ID NO:3);
- IKIWFQNRRMKWKK (SEQ ID NO:4);
- KIWFQNRRMKWKK (SEQ ID NO:5);
- IWFQNRRMKWKK (SEQ ID NO:6);
- WFQNRRMKWKK (SEQ ID NO:7);
- FQNRRMKWKK (SEQ ID NO:8);
- QNRRMKWKK (SEQ ID NO:9);
- NRRMKWKK (SEQ ID NO:10);
- RRMKWKK (SEQ ID NO:11);
- FKSGLKYKK (SEQ ID NO:12);
- KSGLKYKK (SEQ ID NO:13);
- QRLFQVKGRR (SEQ ID NO:14);
- RLFQVKGRR (SEQ ID NO:15);
- YGRKKRRQRRRP (SEQ ID NO:16);
- GRKKRRQRRRP (SEQ ID NO:17);
- RKKRRQRRRP (SEQ ID NO:18);
- RKKRRQRRRPGG (SEQ ID NO:19);
- AGRKKRRQARR (SEQ ID NO:20);
- YARKARRQARR (SEQ ID NO:21);
- YARAAARQARA (SEQ ID NO:22);
- YARAARRAARR (SEQ ID NO:23);
- YARAARRAARA (SEQ ID NO:24);
- YARRRRRRRRR (SEQ ID NO:25);
- RKKRRQRRR (SEQ ID NO:26);
- RKKRRQRR (SEQ ID NO:27);
- YGRKKRRQRRR (SEQ ID NO:28);
- YGRKKRRQRR (SEQ ID NO:29);
- GRKKRRQRRR (SEQ ID NO:30);
- GRKKRRQRR (SEQ ID NO:31);
- RRRRR (SEQ ID NO:32);
- RRRRRR (SEQ ID NO:33);
- RRRRRRR (SEQ ID NO:34);
- RRRRRRRR (SEQ ID NO:35);
- RRRRRRRRR (SEQ ID NO:36);
- RRRRRRRRRR (SEQ ID NO:37);
- RRRRRRRRRRR (SEQ ID NO:38);
- and RRRRRRRRRRRR (SEQ ID NO:39).
A method for modulating the secretion of pro-inflammatory cytokines in a cell, the method comprising contacting a cell with a polybasic peptide in an amount effective to modulate the secretion of pro-inflammatory cytokines in a cell.
Dependencies are inferred from the claim text.