Antimicrobial peptides isolated from fish
AssigneeNorth Carolina State University
InventorsEdward J. Noga, Umaporn Silphaduang
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Abstract
Antimicrobial peptides (endobiotic peptides), isolated from fish are described. Such endobiotic peptides may be isolated as 22 amino acid peptides having molecular weights of about 2500 Da from the gills of hybrid striped bass (Morone saxitilis×Morone chrysops). Antibodies that bind such peptides and methods of using such peptides are also described.
Claims20
An antimicrobial compound selected from the group consisting of peptides having an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 1;
- SEQ ID NO:
- 2;
- and
- SEQ ID NO:
- 3.
An antimicrobial compound having an amino acid sequence consisting of:
- SEQ ID NO:
- 4.
A method of monitoring fish health comprising:
- (a) collecting a biological sample from a fish;
- and
- (b) detecting the level of at least one endogenous endobiotic peptide in said sample, wherein lower levels of endobiotic peptides indicate decreased health in said fish.
A method of monitoring freshness of a fish food product, comprising detecting the level of at least one endogenous endobiotic peptide, wherein lower levels of endobiotic peptides indicate decreased freshness in said fish food product.
A method of screening for compounds useful for treating stress in fish, comprising the steps of:
- (a) administering a test compound to a fish;
- (b) collecting a biological sample from said fish;
- and
- (c) detecting the level of at least one endogenous endobiotic peptide in said sample, wherein higher levels of endobiotic peptide in said fish as compared to those found in the absence of administration of said test compound indicate said compound is useful in treating stress in said fish.
Dependencies are inferred from the claim text.