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OwnerAshley Anthony Barnes, Alan Wise +4inventors
InventorsAshley Anthony Barnes, Alan Wise, Fiona Hamilton Marshall, Neil James Fraser, Julia Helen Margaret White, Steven Michael Foord
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The present invention relates to the novel GABAB receptor subtypes GABAB-R1c and GABAB-R2 as well as to a novel, functional GABAB receptor which comprises a heterodimer of GABAB-R1 and GABAB-R2 receptor subunits. The present invention also relates to variants of the receptors, nucleotide sequences encoding the receptors and variants thereof and novel vectors, stable cell lines, antibodies, screening methods, methods of treatment and methods of receptor production.
An isolated GABAB-R2 receptor protein or a variant thereof.
An isolated GABAB-R2 receptor protein having amino acid sequence provided in FIG. 1B, or a variant thereof.
A nucleotide sequence encoding a GABAB-R2 receptor or a variant thereof, or a nucleotide sequence which is complementary thereto.
A nucleotide sequence encoding a GABAB-R2 receptor, as shown in FIG. 1A, or a variant thereof, or a nucleotide sequence which is complementary thereto.
An isolated GABAB-R1c receptor protein or a variant thereof.
An isolated GABAB-R1c receptor protein having amino acid sequence provided in FIG. 2, or a variant thereof.
A nucleotide sequence encoding a GABAB-R1c receptor protein or a variant thereof, or a nucleotide sequence which is complementary thereto.
A GABAB receptor comprising an heterodimer between a GABAB-R1 receptor protein or a variant thereof and a GABAB-R2 receptor protein or a variant thereof.
An expression vector comprising a nucleotide sequence encoding for a GABAB-R1 receptor or a variant thereof and a nucleotide sequence encoding for a GABAB-R2 receptor or variant thereof, said vector being capable of expressing both a GABAB-R1 and a GABAB-R2 receptor proteins or variants thereof.
A stable cell line modified to express both GABAB-R1 and GABAB-R2 receptor proteins or variants thereof.
A method of producing a GABAB receptor comprising introducing into an appropriate cell line a suitable vector or vectors comprising nucleotide sequences encoding for GABAB-R1 and GABAB-R2 receptors or variants thereof, under conditions suitable for obtaining expression of the receptors or variants.
Dependencies are inferred from the claim text.