Treatment for central nervous system disorders
OwnerJoseph F. Poduslo, Geoffry L. Curraninventors
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Abstract
Compositions that include an Aβ polypeptide linked to a non-Aβ polypeptide are described, as well as methods of using such compositions.
Claims30
A composition comprising an amyloid β(Aβ) polypeptide and a non-Aβ polypeptide, wherein said Aβ polypeptide and said non-Aβ polypeptide are linked.
A method of treating a patient diagnosed with Alzheimer's disease, said method comprising administering to said patient an amount of a composition effective to treat Alzheimer's disease, said composition comprising an Aβ polypeptide and an antibody having specific binding affinity for said Aβ polypeptide.
A method of treating a patient diagnosed with Alzheimer's disease, said method comprising administering to said patient an amount of an antibody effective to treat Alzheimer's disease, wherein said antibody is polyamine modified and has specific binding affinity for an Aβ polypeptide.
A method of diagnosing Alzheimer's disease in a patient, said method comprising a) administering a composition to said patient, wherein said composition comprises an Aβ polypeptide and an antibody having specific binding affinity for amyloid, wherein said antibody is labeled, and b) detecting the presence or absence of said antibody bound to amyloid in the brain of said patient, wherein said patient is diagnosed with Alzheimer's disease based on the presence of labeled amyloid in the brain of said patient.
Dependencies are inferred from the claim text.