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US 2003/0077679 A1Published application
Methods for finding modulators of DYRK3 and DYRK2
OwnerRoland S. Annan, Brian M. Burns +2inventors
InventorsRoland S. Annan, Brian M. Burns, Caretha Lee Creasy, Kathleen M. Herold
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Abstract
Methods of finding agonists and antagonists to DYRK3 or DYRK2 are provided.
Claims16
A method of identifying an agonist or antagonist of human DYRK2 (SEQ ID NO:6), said method comprising the steps of:
- (a) incubating a candidate compound with human DYRK2 (SEQ ID NO:6);
- and
- (b) determining the amount of phosphorylation of human EID-1 (SEQ ID NO:4) by human DYRK2 (SEQ ID NO:6);
- and
- (c) identifying a compound that promotes the phosphorylation human EID-1 (SEQ ID NO:4) as an agonist of human DYRK2 (SEQ ID NO:6), and a compound that decreases the phosphorylation of human EID-1 (SEQ ID NO:4) as an antagonist of human DYRK2 (SEQ ID NO:6).
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A method of identifying an agonist or antagonist of DYRK3, said method comprising the steps of:
- (a) incubating a candidate compound with a DYRK3 selected from group consisting of:
- murine DYRK2 (SEQ ID NO:3) and human DYRK3 (SEQ ID NO:2);
- and
- (b) measuring the amount of phosphorylation of human EID-1 (SEQ ID NO:4) by said DYRK3;
- and
- (c) identifying a compound that promotes the phosphorylation of human EID-1 (SEQ ID NO:4) as an agonist of said DYRK3 selected from group consisting of:
- murine DYRK2 (SEQ ID NO:3) and human DYRK3 (SEQ ID NO:2), and a compound that decreases the phosphorylation of human EID-1 (SEQ ID NO:4) as an antagonist of said DYRK3 selected from group consisting of:
- murine DYRK2 (SEQ ID NO:3) and human DYRK3 (SEQ ID NO:2).
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Dependencies are inferred from the claim text.