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AssigneeTrophos
InventorsPacal Villa, Michel Delaage, Toni Wiliamson, Christopher Henderson
Estimating the term…
The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.
A method of identifying compounds active on neuronal cell function, said method comprising:
A method for identifying compounds active on neuronal survival or neuronal development, said method comprising:
A method of identifying, selecting or characterizing a compound active on neuronal cell function, comprising contacting one or several candidate compounds in parallel with:
A method of identifying, selecting or characterizing a compound active on neuronal cell function, comprising contacting one or several candidate compounds in parallel with:
A method of screening a library of compounds, comprising testing each or some compounds of the library for their activity on one or several isolated neuronal cell populations.
An essentially pure culture of isolated hippocampal neurons.
An essentially pure culture of isolated forebrain cholinergic neurons.
A kit for use in assessing the neuro-activity of a candidate compound, comprising an isolated neuronal cell population, a support and, optionally, means to induce metabolic alteration(s) to the neurons and/or means to assess any metabolic change in a neuronal population.
Dependencies are inferred from the claim text.